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Without adequate glutathione, detoxification stalls, oxidative damage accelerates, and the immune system cannot self-regulate effectively

Melatonin attenuates the postischemic increase in blood-brain barrier permeability and decreases hemorrhagic transformation of tissue-plasminogen activator therapy following ischemic stroke in mice

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In formulating a controlled-release formulation, it is advised to avoid or combine the appropriate excipients, diluents or carriers to lessen or eliminate potential ototoxic components from the formulation, or to decrease the amount of such excipients, diluents, or carriers

doi: 10.1016/j.expneurol.2007.01.005

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